Association between Mannose-Binding Lectin Deficiency and Septic Shock following Acute Pyelonephritis Due to Escherichia coli
نویسندگان
چکیده
منابع مشابه
Association between deficiency of mannose-binding lectin and severe infections after chemotherapy.
The plasma protein mannose-binding lectin (MBL) activates the complement system by binding to carbohydrate structures presented by microorganisms and thus could be an important component of the innate immune defence system. We measured MBL in patients with leukaemia who were scheduled to undergo chemotherapy (ie, a population especially susceptible to infection) and related the results to sever...
متن کاملThe Role of Mannose-Binding Lectin in Severe Sepsis and Septic Shock
Severe sepsis and septic shock are a primary cause of death in patients in intensive care unit (ICU). Investigations upon genetic susceptibility profile to systemic complications during severe infections are a field of increasing scientific interest. Particularly when adaptive immune system is compromised or immature, innate immunity plays a key role in the immediate defense against invasive pa...
متن کاملMannose-binding lectin deficiency with eosinophilic meningoencephalitis due to Angiostrongylus cantonensis in children: a case series
INTRODUCTION Eosinophilic meningitis, a potentially fatal disease caused by Angiostrongylus cantonensis, is considered an emerging infectious disease. CASE PRESENTATION Three Caucasian boys (aged five-years-old, 10-years-old and six-years-old) with a diagnosis of eosinophilic meningoencephalitis caused by Angiostrongylus cantonensis were studied. Serum immunoglobulin A (IgA), IgM, IgG, and co...
متن کاملIs mannose-binding lectin deficiency associated with infection due to Gram-positive bacteria?
To the Editor—We read with great interest the article by Eisen et al. [1], in which the authors report an ambitious multivariable analysis of several articles on the impact of mannose-binding lectin (MBL) deficiency on the outcome of severe bacterial infection and sepsis. Although genetic polymorphisms in the genes encoding different molecules of the innate immune system have been associated wi...
متن کاملMannose-binding lectin is a critical factor in systemic complement activation during meningococcal septic shock.
BACKGROUND Systemic activation of complement during meningococcal disease is associated with severe disease and poor outcome. The exact mechanism of activation of complement is unknown but is important for future therapies aimed at modulating the complement system in this disease. METHODS We studied complement activation in a group of 22 patients, including 18 with meningococcal septic shock ...
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ژورنال
عنوان ژورنال: Clinical and Vaccine Immunology
سال: 2007
ISSN: 1556-6811,1556-679X
DOI: 10.1128/cvi.00400-06